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  • Anti-EGFR Monoclonal Antibody
產(chǎn)品名稱：

Anti-EGFR Monoclonal Antibody
產(chǎn)品品牌： SOLARBIO/索萊寶 價格：
廠商性質(zhì)： 生產(chǎn)廠家 產(chǎn)品時間： 2022-08-15
Anti-EGFR Monoclonal Antibody
應用 WB IF IHC
稀釋比例WB 1:500-2000. IF 1:100-200. IHC 1:200-500.
交叉反應Human

產(chǎn)品概述

品牌SOLARBIO/索萊寶貨號K200050M
規(guī)格50ul/100ul供貨周期現(xiàn)貨
主要用途WB IF IHC應用領域醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)林牧漁

Anti-EGFR Monoclonal Antibody

英文名稱Anti-EGFR Monoclonal Antibody
宿主Mouse
別名Epidermal growth factor receptor;erbb 1;Receptor tyrosine protein kinase ErbB 1
應用WB IF IHC
稀釋比例WB 1:500-2000. IF 1:100-200. IHC 1:200-500.
交叉反應Human
蛋白分子量170kDa
Gene ID1956
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG1
免疫原A synthetic peptide coupled to KLH
性狀液體
Public Immunogen RangeA synthetic peptide coupled to KLH
Subcellular LocationsNucleus Endosome Plasma membrane Golgi apparatus Endoplasmic reticulum secreted
Swiss ProtP00533
克隆號1B1
克隆類型Monoclonal Antibody
背景資料The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascadesβ-Actin is one of six different actin isoforms that have been identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical properties. Therefore, Antibodies against β-Actin are useful as loading controls for Western Blotting. However it should be noted that levels of β-Actin may not be stable in certain cells. For example, expression of β-Actin in adipose tissue is very low and therefore β-Actin should not be used as loading control for these tissues.

 

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