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        • Anti-EGFR Monoclonal Antibody
        產(chǎn)品名稱:

        Anti-EGFR Monoclonal Antibody

        產(chǎn)品品牌: SOLARBIO/索萊寶 價(jià)格:
        廠商性質(zhì): 生產(chǎn)廠家 產(chǎn)品時(shí)間: 2022-08-15
        Anti-EGFR Monoclonal Antibody
        應(yīng)用 WB IF IHC
        稀釋比例WB 1:500-2000. IF 1:100-200. IHC 1:200-500.
        交叉反應(yīng)Human

        產(chǎn)品概述

        品牌SOLARBIO/索萊寶貨號K200050M
        規(guī)格50ul/100ul供貨周期現(xiàn)貨
        主要用途WB IF IHC應(yīng)用領(lǐng)域醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)林牧漁

        Anti-EGFR Monoclonal Antibody

        英文名稱Anti-EGFR Monoclonal Antibody
        宿主Mouse
        別名Epidermal growth factor receptor;erbb 1;Receptor tyrosine protein kinase ErbB 1
        應(yīng)用WB IF IHC
        稀釋比例WB 1:500-2000. IF 1:100-200. IHC 1:200-500.
        交叉反應(yīng)Human
        蛋白分子量170kDa
        Gene ID1956
        保存Store at -20°C. Avoid freeze / thaw cycles.
        儲(chǔ)存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
        純化方法Affinity purification
        亞型IgG1
        免疫原A synthetic peptide coupled to KLH
        性狀液體
        Public Immunogen RangeA synthetic peptide coupled to KLH
        Subcellular LocationsNucleus Endosome Plasma membrane Golgi apparatus Endoplasmic reticulum secreted
        Swiss ProtP00533
        克隆號1B1
        克隆類型Monoclonal Antibody
        背景資料The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascadesβ-Actin is one of six different actin isoforms that have been identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical properties. Therefore, Antibodies against β-Actin are useful as loading controls for Western Blotting. However it should be noted that levels of β-Actin may not be stable in certain cells. For example, expression of β-Actin in adipose tissue is very low and therefore β-Actin should not be used as loading control for these tissues.

         

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