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  • Anti-PCNA Polyclonal Antibody
產(chǎn)品名稱：

Anti-PCNA Polyclonal Antibody
產(chǎn)品品牌： SOLARBIO/索萊寶 價格：
廠商性質： 生產(chǎn)廠家 產(chǎn)品時間： 2022-08-15
Anti-PCNA Polyclonal Antibody
應用 WB
稀釋比例WB 1:500-2000.
交叉反應Human Mouse Rat

產(chǎn)品概述

品牌SOLARBIO/索萊寶貨號K101310P
規(guī)格50ul/100ul供貨周期現(xiàn)貨
主要用途WB應用領域醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)林牧漁

Anti-PCNA Polyclonal Antibody

英文名稱Anti-PCNA Polyclonal Antibody
宿主Rabbit
別名ATLD2;cb16;Cyclin;HGCN872;MGC8367
應用WB
稀釋比例WB 1:500-2000.
交叉反應Human Mouse Rat
蛋白分子量29kDa
Gene ID5111
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原A synthetic peptide of human PCNA
性狀液體
Public Immunogen RangeA synthetic peptide of human PCNA
Subcellular LocationsNucleus
Swiss ProtP12004
克隆類型Polyclonal Antibody
背景資料Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

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