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        • Anti-CD8 Polyclonal Antibody
        產(chǎn)品名稱:

        Anti-CD8 Polyclonal Antibody

        產(chǎn)品品牌: SOLARBIO/索萊寶 價(jià)格:
        廠商性質(zhì): 生產(chǎn)廠家 產(chǎn)品時間: 2022-08-15
        Anti-CD8 Polyclonal Antibody
        應(yīng)用 WB
        稀釋比例WB 1:3000.
        交叉反應(yīng)Mouse

        產(chǎn)品概述

        品牌SOLARBIO/索萊寶貨號K106402P
        規(guī)格50ul/100ul供貨周期現(xiàn)貨
        主要用途WB應(yīng)用領(lǐng)域醫(yī)療衛(wèi)生,環(huán)保,生物產(chǎn)業(yè),農(nóng)林牧漁

        Anti-CD8 Polyclonal Antibody

        英文名稱Anti-CD8 Polyclonal Antibody
        宿主Rabbit
        別名CD8A;MAL;Leu2;p32;OKT8 T cell antigen
        應(yīng)用WB
        稀釋比例WB 1:3000.
        交叉反應(yīng)Mouse
        蛋白分子量28kDa
        Gene ID925
        保存Store at -20°C. Avoid freeze / thaw cycles.
        儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
        純化方法Affinity purification
        亞型IgG
        免疫原A synthetic peptide of human CD8
        性狀液體
        Public Immunogen RangeA synthetic peptide of human CD8
        Subcellular LocationsCell membrane
        Swiss ProtP01732
        克隆類型Polyclonal Antibody
        背景資料Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

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