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        • Anti-GSK3B Polyclonal Antibody
        • Anti-GSK3B Polyclonal Antibody
        • Anti-GSK3B Polyclonal Antibody
        • Anti-GSK3B Polyclonal Antibody
        產(chǎn)品名稱:

        Anti-GSK3B Polyclonal Antibody

        產(chǎn)品品牌: SOLARBIO/索萊寶 價(jià)格:
        廠商性質(zhì): 生產(chǎn)廠家 產(chǎn)品時(shí)間: 2022-08-15
        Anti-GSK3B Polyclonal Antibody
        應(yīng)用 WB IHC
        稀釋比例WB 1:500-2000 IHC 1:50-200.
        交叉反應(yīng)Mouse Rat

        產(chǎn)品概述

        品牌SOLARBIO/索萊寶貨號K101564P
        規(guī)格50ul/100ul供貨周期現(xiàn)貨
        主要用途WB IHC應(yīng)用領(lǐng)域醫(yī)療衛(wèi)生,環(huán)保,化工,生物產(chǎn)業(yè),農(nóng)林牧漁

         

        Anti-GSK3B Polyclonal Antibody

        英文名稱Anti-GSK3B Polyclonal Antibody
        宿主Rabbit
        別名GSK-3 beta;Glycogen Synthase Kinase 3 Beta;GSK3beta isoform;Serine/threonine-protein kinase GSK3B
        應(yīng)用WB IHC
        稀釋比例WB 1:500-2000 IHC 1:50-200.
        交叉反應(yīng)Mouse Rat
        蛋白分子量47kDa
        Gene ID2932
        保存Store at -20°C. Avoid freeze / thaw cycles.
        儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
        純化方法Affinity purification
        亞型IgG
        免疫原A synthetic peptide of human GSK3B
        性狀液體
        Public Immunogen RangeA synthetic peptide of human GSK3B
        Subcellular LocationsCell membrane Cytoplasm Nucleus
        Swiss ProtP49841
        克隆類型Polyclonal Antibody
        背景資料Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation.

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